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DeGregori, James

One or more keywords matched the following items that are connected to DeGregori, James

Item Type	Name
Academic Article	Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity.
Academic Article	Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes.
Academic Article	Declining cellular fitness with age promotes cancer initiation by selecting for adaptive oncogenic mutations.
Academic Article	Surprising dependency for retinoblastoma protein in ras-mediated tumorigenesis.
Academic Article	Tumor necrosis factor alpha-induced apoptosis requires p73 and c-ABL activation downstream of RB degradation.
Academic Article	Ionizing radiation and hematopoietic malignancies: altering the adaptive landscape.
Academic Article	Challenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age?
Concept	Models, Biological
Academic Article	Stochastic modeling indicates that aging and somatic evolution in the hematopoetic system are driven by non-cell-autonomous processes.
Academic Article	Toward an evolutionary model of cancer: Considering the mechanisms that govern the fate of somatic mutations.
Academic Article	The evolution of lifespan and age-dependent cancer risk.
Academic Article	A generalized theory of age-dependent carcinogenesis.
Academic Article	A somatic evolutionary model of the dynamics of aneuploid cells during hematopoietic reconstitution.

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